Abstract

PHARMACOLOGICAL SCREENING OF ROSMARY OIL ON LEARNING AND MEMORY IN RATS

Manoj Kumar*, Rizwana Bee and Dr. K. K. Maheshwari

Abstract

Present research work was performed to evaluate the learning and memory improving activity of rosemary in rat by using double y- maze test. A behavioural abnormality was studied in rats by using double y maze test. Rats of either sex were divided into 4 groups of 6 animals in each group. Group I- DMSO control, Group II- Rosemary (300 mg/kg) treated Group III- Rosemary (300 mg/kg) + Piracetam (100 mg/kg), Piracetam (100 mg/kg) standard. All the test solution were freshly prepared daily and administered to animal for 5 days by oral route. On first day, second day, third day, fourth day, and fifth day, each animal was checked to evaluate learning and memory improving effect by using double y- maze. Our result showed that rosemary (300 mg/kg), rosemary 300 mg/kg + Piracetam 100 mg/kg and Piracetam (100 mg/kg) significantly increases the number of entries into reference arm and working arm and in the double ymaze test rosemary (300 mg/kg), rosemary (300 mg/kg) + Piracetam (100 mg/kg) and Piracetam showed the significantly increased the number of entries in the goal arm and decreasing the latency time to reaches the goal arm. These result support that rosemary (300 mg/kg) improving the learning and memory effect. Rosemary 300 mg/kg is sufficient dose to give learning and memory improving effect in rats. Rosemary is less potent than Piracetam in rat.

Keywords: Rosemary Oil, Piracetam and double Y-maze.