PHARMACOLOGICAL SCREENING OF ROSMARY OIL ON LEARNING AND MEMORY IN RATS
Manoj Kumar*, Rizwana Bee and Dr. K. K. Maheshwari
Abstract
Present research work was performed to evaluate the learning and
memory improving activity of rosemary in rat by using double y- maze
test. A behavioural abnormality was studied in rats by using double y
maze test. Rats of either sex were divided into 4 groups of 6 animals in
each group. Group I- DMSO control, Group II- Rosemary (300 mg/kg)
treated Group III- Rosemary (300 mg/kg) + Piracetam (100 mg/kg),
Piracetam (100 mg/kg) standard. All the test solution were freshly
prepared daily and administered to animal for 5 days by oral route. On
first day, second day, third day, fourth day, and fifth day, each animal
was checked to evaluate learning and memory improving effect by
using double y- maze. Our result showed that rosemary (300 mg/kg),
rosemary 300 mg/kg + Piracetam 100 mg/kg and Piracetam (100 mg/kg) significantly
increases the number of entries into reference arm and working arm and in the double ymaze
test rosemary (300 mg/kg), rosemary (300 mg/kg) + Piracetam (100 mg/kg) and
Piracetam showed the significantly increased the number of entries in the goal arm and
decreasing the latency time to reaches the goal arm. These result support that rosemary (300
mg/kg) improving the learning and memory effect. Rosemary 300 mg/kg is sufficient dose to
give learning and memory improving effect in rats. Rosemary is less potent than Piracetam in
rat.
Keywords: Rosemary Oil, Piracetam and double Y-maze.
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