Abstract

FORMULATION AND EVALUTION OF TELMISARTAN SOLID DISPERSION USING DIFFERENT POLYMERS

Y. Phalguna*, Swetha Pothula and Yashasree

Abstract

The goal of this examination was to plan and assess solid dispersion of Telmisartan to build dissolvability and for improvement of bioavailability. The solid dispersion were set up by physical blend strategy utilizing PEG 20000, PEG 6000, HPMC E15, HPC LH21, β- Cyclodextrin as a bearer in different proportions. Improved solid dispersion was assessed for % CDR and Time for CDR, FTIR, and in vitro tranquilize discharge study. The outcomes indicated that among the different groups containing the polymer being utilized in the examination, F8 plan containing critical improvement in solvency and disintegration profile of the medication.

Keywords: Telmisartan, Solid dispersion, Physical Mixture method, Invitro studies.