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Abstract

EXCISION AND INCISION WOUND HEALING ACTIVITY OF STEM BARK AQUEOUS EXTRACT OF BAUHINIA VARIEGATA LINN. IN DIABETIC ALBINO RATS

Rajeev Kumar*, Bhupendra Nath Dwivedy, Anil Bhandari, Rajesh Kumar Nema

Abstract

The basic objective of the present work was to assess the wound healing activity of aqueous extract of Bauhinia variegata stem bark by providing better tissue formation and protection against microbial invasion. The stem bark of Bauhinia variegate were subjected for extraction with aqueous. Various ointments of extracts in various proportions were prepared and subjected for assessment of wound healing activity in diabetic albino rats using four parameters i.e., Wound contraction studies (Excision Wound), Tensile strength measurement (Incision Wound), Hydroxyproline content determination (Incision Wound) and Histopathological studies (Incision Wound).Based on the comparison of wound healing activity of various formulations, the formulation comprising of 4% (w/w) aqueous extract of stem bark of Bauhinia variegata found to be superior to that of control and standard formulation (0.3% w/w neomycin ointment). The present studies evidenced the significant wound healing activity of Bauhinia variegata by increasing cellular proliferation, formation of granular tissue, synthesis of collagen and by increase in the rate of wound contraction.

Keywords: Excision, Incision, Bauhinia variegata, wound contraction, cellular proliferation, collagen, granular tissue.


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