Abstract

HISTOPATHOLOGICAL CHANGES IN THE LIVER AND KIDNEY TISSUES OF ALBINO WISTAR RATS FED VARIOUS PREPARATIONS OF DICHLORVOS-TREATED BEANS

Darlington O. Nwauzobilom*, Paulinus C. Nwuke, Christian E. Odo and Ibeh Bartholomew

Abstract

This study was aimed at evaluating the effects of differently prepared (parboiled and un-parboiled) beans treated with sniper (i.e. a dichlorvos based insecticide) on the histological architecture of liver and kidney of albino wistar rats. Thirty (30) male albino wistar rats of known body weights were assigned into six (6) groups of 5 rats each. The beans were treated with 0.7mil (high dose) and 0.3 mil (low dose) of dichlorvos per one kg of beans. Group 1 and group 2 of unparboiled beans compounded with standard feed stock, group 3 and group 4 were fed with high dose and low dose of parboiled beans compounded with feed stock, group 5 received beans only while group 6 received standard feed for a period of 30 days. The experimental animals were euthanized at the end of the study period. Tissue sections of the liver and kidney were collected for histopathological studies. The histopathological results showed normalcy in the kidneys of all the rat groups but moderate vacuolar degeneration of hepatocytes and mild to moderate, multifocal and random hepatocellular necrosis with mild infiltration of phagocytic leucocytes were seen in the group fed with high concentration dichlorvos-treated beans for both the parboiled (group 1) and un-parboiled (group 3).

Keywords: Dichlorvos, histopathology; liver and kidney.