Abstract

A REVIEW SYNTHESIS, EVALUATION AND QSAR STUDY OF SUBSTITUTED 1, 2, 4 TRIAZOLE NUCLEUS

Anurag Singh*, Dr. Ameeta Argal, Dr. Digivijay Kumer and Dr. Surendra Kumar Jain

Abstract

Heterocyclic chemistry has now become a separate field of chemistry with long history, present society and future prospects. Synthesis of new chemical entities is major bottleneck in drug discovery. The earliest compounds known to mankind were of heterocyclic origin. Life, like ours, is totally dependent on the heterocyclic compounds heterocyclic chemistry delivers reagents and synthetic methods of its own traditional activity in synthesis of drugs, pesticides and detergents as well as into the related fields such as biochemistry, polymers and material sciences Five-membered nitrogen heterocycle compounds are important structural fragments and considered as biologically active compounds, corrosion inhibitors, pesticides, dyes, acid- base indicator, and other industrial chemicals. This review article covers the latest information over active triazole derivatives having different pharmacological action such as, antiviral, anticonvulsant, anti-inflammatory, antibacterial, antifungal and antituberculosis anxiolytics, anti-convulsants, antimigraine, antihistaminics, CNS stimulants It can act as an important tool for medicinal chemists to develop newer compounds possessing triazole moiety that could be better agents in terms of efficacy and safety. QSAR relies on the basic assumption that molecules with similar physicochemical properties or structures. QSAR is a statistical model that relates a set of structural descriptor of a chemical compound to its biological compound. QSAR studies predict the biological activity, physiochemical properties of the molecules and explain the target of the molecules, which part of synthesized molecule is responsible for the activity. Prediction could reduce the requirement for lengthy and expensive animal tests QSAR study is use full for the large amount of biological target information is the available in the microbiology. Automation of chemical synthesis and pharmacological screening has also provided a vast amount of experimental data.

Keywords: Antifungal, QSAR, Antibacterial activity. Einhorn–Brunner reaction Dimroth Reaction. Pellizzari Reaction.