Abstract

REVIEW ON ANTIULCER AGENTS FROM MEDICINAL PLANTS

Akshay Chandrakant Raut*, Shaikh Nehaparveen Mustafa*, Shaikh Shaukat Akbar*, Sagar S. Muley* and Sunil D. Kolhe

Abstract

A peptic ulcer is erosion in a segment of the gastro intestinal mucosa. It may typically in the stomach (gastric ulcer) or first few centimeters of duodenum (duodenal ulcer) that penetrates through the muscular is mucosae. Contrary to popular belief, ulcer is not only caused by spicy food but also most commonly due to an infection of Helicobacter Pylori and long term use of medications. Standard treatment is a combination of drugs including antibiotics and a proton pump inhibitors. Floating matrix tablets of Lansoprazole were developed to prolong gastric residence time, leading to sustained action of the drug. Tablets were prepared by wet granulation technique, using hydroxypropylmethyl cellulose as a polymer in two different grades, HPMC K4M and HPMC K15M. Tablets were evaluated for their physical characteristics, viz., hardness, thickness, friability, mass variation, drug content and

Keywords: Peptic ulcer herbal drug.