Abstract

REVIEW: SOLUBILITY ENHANCEMENT BY ADVANCE TECHNIQUES - LYOPHILIZATION, SPRAY DRYING AND ROTARY EVAPORATOR METHOD

Gade N. R.*, Shelke M. M., Vare S. R. and Gowekar N. M.

Abstract

Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Poorly watersoluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. Most of drugs weakly acidic and weakly basic with poor aqueous solubility. Hence various techniques are used for the improvement of the solubility of poorly water-soluble drugs include micronization, chemical modification, pH adjustment, solid dispersion, complexation, co‐solvency, micellar solubilization, hydrotropy etc. The purpose of this review article is to describe the techniques of solubilization for the attainment of effective absorption and improved bioavailability.

Keywords: Solubility, solubility enhancement, co-solvent, pH, emulsions.