Abstract

NANOSTRUCTURED LIPID CARRIER: AN ADVANCEMENT IN TOPICAL DRUG DELIVERY SYSTEM

*Ashwini Sable, Prof. Trusha Shangrapawar and Dr. Ashok Bhosale

Abstract

Most of the topical medications which are applied on the skin or mucous membrane to treat ailments include a wide range of creams, foams, gels, lotions, ointments, eye drops, ear drops, etc. Topical drug delivery provides a convenient and effective system for the treatment of local pathological conditions (dermal drug delivery) or as the site for systemic drug administration (transdermal drug delivery). The skin is the largest organ of the human body and easily accessible. It’s potential as an alternative route for administering drugs for both systemic and local effects has attracted considerable interest. The scientific literature today provides several systems which will deliver active pharmaceutical ingredients (APIs) across the skin. These include reservoir matrices, matrix diffusion-controlled devices, multiple polymer devices and multilayer matrix assemblies. Among these, topical application of the Solid lipid nanoparticles(SLN) Nanostructured lipid carriers (NLC) have emerged as novel systems composed of physiological lipid materials suitable for topical, dermal and transdermal administration. NLC’s are a completely unique sort of DDS which are stable in several environment and which have capabilities to make concentrated dispersions. In this review, we discussed different process variables, steps involved in the manufacturing of NLC and responses with their outcome. Nanostructured Lipid Carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. It has been shown that NLCs exhibit several advantages for drug therapy over conventional carriers including increased solubility and stability, improved permeability and bioavailability, reduced adverse effects, prolonged half-life, and tissue-targeted delivery. This review presents advantages of NLC, Types of NLC, Method of preparation of it and characterization of NLC by different analytical methods.

Keywords: TDDS, Solid lipid nanoparticles, NLC, types of NLC, Nano technology.