Abstract

ENHANCEMENT OF AQUEOUS SOLUBLITY OF AZELNIDIPINE USING SOLVENT EVAPORATION TECHNIQUE

Ankita G. Galam*, Dr. Sadhana R. Shahi and Nityanand Zadbuke

Abstract

The present study was aimed to improve the solubility and bioavailability of water insoluble antihypertensive agent Azelnidipine by solvent evaporation method. Chemically Azelnidipine is dihydropyridine analogue. Azelnidipine is voltage dependent inhibitor of trans-membrane Ca2+ influx in vascular smooth muscles. Solid dispersion of Azelnidipine was prepared using hydrophilic polymers by solvent evaporation technique. Further preparations were analysed for solubility study, FTIR study, PXRD study, and Stability Studies. Based on physical characters and drug release patterns formulations F3C, F7C and F11C exhibited best results when compared to pure dug.

Keywords: Solid dispersion, Solvent evaporation, Solubility, BCS Class II, Antihypertensive.