Abstract

EVALUATION OF ANTINEOPLASTIC ACTIVITY OF ETHANOLIC LEAVES EXTRACT OF TYLOPHORA INDICA

Aayesha Rabiya, Dr.Vivek V. Paithankar*, Jugal Kishor Vyas, Anjali Wankhade, Apurva C. Kochar

Abstract

Aim and objective: Main objective of present study to evaluate antineoplastic activity of ethanolic leave extract of Tylophora indica with 7,12 dimethylbenza [a]anthracene (DMBA) as a inducer for skin tumor in mice. Material and Methods: Skin tumors were induced in Swiss albino mice by a single topical application of 7,12- dimethylbenz(a)anthracene (100 mg/100 mL acetone) and, 2week later, promoted by repeated applications of croton oil (thrice in a week in 1% acetone) till the end of the experiment (i.e., 16 week). five groups of six Swiss albino mice in each group were used. First group treated with the carcinogen alone second group treated with the carcinogen with standard drug CP(50mg/kg) and Mice of third, fourth, and fifth group were treated with carcinogen along with the ethanolic extract of Tylophora indica. at 100 mg/kg, 200mg/kg and 400mg/kg was orally administered. Result: Tylophora indica extract treatment caused a significant reduction in tumor incidence, tumor yield, and tumor burden, as compared to the 7, 12-dimethylbenz(a)anthracene croton oil-treated control group. Conclusion: These results suggest that Tylophora indica extract has the potential to become a antitneoplastic agent that can reduce skin cancer in mammals.

Keywords: skin carcinogenesis, DMBA, Croton oil, Tylophora indica.