Abstract

FORMULATION AND EVALUATION OF ORAL DISSOLVING FILMS OF ONDANSETRON HCL

*Arushi Saxena

Abstract

The present research was done to formulate an oral dissolving film of ondansetron Hcl with the objective to attain maximum therapeutic efficacy, patient compliance by decreasing the dosing frequency and other problems associated with conventional or parenteral formulation. Ondansetron Hcl is an antiemetic drug developed to control cancer chemotherapy/radiotherapy induced vomiting and later found to be highly effective in Postoperative nausea and vomiting and disease/drug associated vomiting as well. The oral dissolving films were prepared by using solvent casting method with varying concentrations of HPMC and PVA. The formulated films were evaluated under standard procedures of various physicochemical parameters, drug release and disintegration. The formulated films were found uniform in thickness, with good folding endurance (>300) and having surface pH similar to that of buccal cavity. The drug release showed that the formulation F5 showed the highest drug release which was around 91.6% in 5 minutes. The drug release was found in the order F5>F1>F4>F2>F3. Formulation F5 was best not only in terms of drug release but also had highest drug content and minimum disintegration time. Hence the films containing more concentrations of PVA were found to be better than the films containing HPMC.

Keywords: Ondansetron Hcl, solvent casting method, HPMC, PVA, drug release.