Abstract

A REVIEW ON ANTIMICROBIAL RESISTANCE IN INDIAN NEONATAL AND PEDIATRIC BLOOD STREAM

Ayilulliyil Lubna*, Dr. Jeena Beegum N., Dr. Shijikumar P. S. and Dr. Sirajudheen M. K.

Abstract

Introduction: Antimicrobial resistance is the capability of a microbe to resist the effects of medication that once could successfully treat the microbe. Recently, the increasing trend in drug resistant infections in infants and children has gone relatively unrecognised. The reason for the resistance in microbes being at the forefront of medicine over the past seventy years. It is the selective pressure created by the broad use of antibiotics in agriculture, livestock, veterinary and human medical practices. This result has been an expression of multi drug-resistant organism(MDRS) on a global level in all people (including neonates and children). Aim and Objective: Aim of the review is to determine the patterns of antimicrobial resistance in isolates of blood stream of infants and children in India. As a result of this, ten pathogenic bacterial isolates from the paediatric population in India is studied. Methodology: Nucleic acid amplification method (PCR technique) Agglutination assays DNA micro array technology Blood culture positivity test Data collection from paper and electronic medical records Conclusion: This study identify that antimicrobial resistance is mainly caused by gram positive and negative bacterias. It may results in to divergent epidemiology, severe infections in child soft tissue and upper respiratory tract, allergies, dissemination alternation in porins and efflux pumps of clonal strains etc. As per recognition of this as global health threat. We can find appropriate choices for empiric antibiotic therapy and may contribute to the improvement of infection control, enhance public health education, maternal colonisation and enforcement of regulations.

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