Abstract

FORMULATION AND EVALUATION OF RISPERIDONE FLOATING TABLETS USING NATURAL POLYMERS

Panchaxari Dandagi*, Shubham Rangoli, Udaykumar Bolmal, Rajashree Masareddy, Taufik Kazi

Abstract

The present study is aimed to develop Risperidone floating tablets using natural polymers. Risperidone is a second generation antipsychotic drug. This drug plays major role in the treatment of schizophrenia, bipolar and irritability disorders. Risperidone has good lipophilic behavior, so it is rapidly and completely absorbed through oral route of administration and finally metabolized by cytochrome- P450 2D6. This drug has a narrow absorption window at upper G. I. tract leads to variation in bioavailability makes a suitable candidate for floating drug delivery system. The Risperidone floating tablets were formulated by Direct compression method. Hydrocolloid natural polymers like Gaur gum, Xanthan gum were used as a floating polymers and gelling agent in a different concentration. Sodium bi carbonate was used as a gas generating agent to reduce floating lag time. Drug-excipients compatibility was studied by Differential Scanning Colorimeter (DSC) and Fourier Transform Infrared Spectroscopy (FTIR). All the formulations were subjected for Pre-Compression and Post-Compression parameters. The powder showed good flow properties and Compressibility Index. All the formulated tablets were found within the permissible limits for various Post-compression parameters. Optimized formulation F7, which is combination of both polymers were showed 95% of in vitro drug release up to 12 hours and followed Korsemeyers Peppas release mechanism of kinetics and was governed by non-Fickian diffusion release. Stability studies were carried out for F7 formulation at room temperature and accelerated temperature, results revealed that formulation was found to be stable for 1 month.

Keywords: Risperidone, floating drug delivery system, Gaur gum and Xanthan gum.