Abstract

PREPARATION AND EVALUATION OF IN-SITU OPHTHALMIC GEL OF CHLORAMPHENICOL

Pradnya Nandivadekar*, Prashant Kumar Katiyar, Suchita Ghokhale, Shubham Maurya, Pratik Mhatre and Amit Kumar Mishra

Abstract

Objective: To develop a hydrogel to increase the retention time of a drug in an ophthalmic drug delivery system. Methods: The experiment was conducted on the preparation and evaluation of chloramphenicol ophthalmic hydrogel with various concentrations of sodium alginate, F1 (0.3% sodium alginate), F2 (0.4% sodium alginate), F3 (0.5% sodium alginate), F4 (0.6% sodium alginate). The organoleptic safety, pH, viscocity, sterility and in-vitro drug release were evaluated. Result: F3 formualtion shows gelling capacity over 6 hours and corneal drug release 98.28% for 8hrs. Coclusion: The chloramphenicol hydrogel ophthalmic preparations formulated with HPMC have shown a good characteristic, and acceptable sustained released profile that may extend absorption of the drug for an optimum bioavailability at the site of action.

Keywords: chloramphenicol, hydrogel, hydroxypropyl methylcellulose, ophthalmic.