Abstract

PHYSIOLOGICAL RISK FACTORS AND CLINICO HISTOPATHOLOGICAL CHARACTERISTICS AMONG BREAST CANCER PATIENTS (WOMEN POPULATION) IN QASSIM PROVINCE, SAUDI ARABIA

Dr. Saleh A.E.F AL Gabbany ABFM, JBFM*, Dr. Mohammad Ali Al Habdan, Ph.D, Dr. Paul Faustin Seke Etet, PhD, Dr. Ghada Farouk Khaki, MBBCh,EBR EDBi, Dr. Lorella Vecchio, Ph.D, Dr.K.Chandra Sekhar, M.D., Dr. Mohmaad Farhna Ph.D.

Abstract

Background: Breast cancer is most common cancer in the world including developing and developed world. It accounts 1.7 million cases diagnosed globally in the year 2012 and it accounts 25% of all cancers in women. (https://www.wcrf.org) Objectives: To find the physiological risk factors and histopathological characteristics among the Breast cancer patients of women aged between 35 to 60 yrs in Qassim province. Methodology: We performed a retrospective study of the baseline and clinico histopathological features of the asymptomatic cases detected between January 2007 and December 2014 by the digital mammography Screening program of Qassim region, central Saudi Arabia. These features were further investigated by immunohistochemistry in the young women diagnosed (35 to 40 years old) and compared to older (41-45 yrs and more than 45 yrs). Results: Numerous women were sensitized about breast cancer and mammography, up to 47% of the cases detected were younger than 45 years (yrs). Breast cancer severity score decreased with the age at first pregnancy and increased with the age at diagnosis, the age at menarche and the body mass index (BMI). Up to 49% of cases were diagnosed with invasive ductal carcinoma. The location of mammography signs changed with the age at diagnosis. Conclusions: Based on the study results, Breast cancer awareness campaigns were successful in central province of Saudi Arabia. The occurrence of many asymptomatic cases before the age of 45 yrs underlines the need for screening women from earlier age and to implement mammography screening programs all over Saudi Arabia considering the benefits of early detection of breast cancer and benefit of reduction of treatment cost. Need large sample similar studies are required to substantiate the present study results.

Keywords: Age, Breast cancer, Cancer Severity, Clinico pathological characteristics, Qassim.