Abstract

ADVANCES IN NANO DRUG DELIVERY FOR THE TREATMENT OF ACNE: A REVIEW

Pankaj*, Prof. Dr. P. K. Sahoo and Jitender Pratap Yadav

Abstract

Acne Vulgaris is inflammatory skin disorder by which approximately 95% of the population suffers at some point in their lifespan. Acne is a multifactorial disease of pilosebaceous units. This disorder is most common in adolescents but also effect prepubescent neonates, children‟s and adults. Topical treatments of Acne are associated with various side effects like skin Irritation, Dryness, Peeling, Itching etc. Novel drug delivery systems have been used to reduce the side effect of topically used Drugs. Topical treatment of acne makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. Furthur, we also discuss the advantages, disadvantages, and outcome of using various micro/ Nanoparticulate delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system.

Keywords: Acne vulgaris, novel drug delivery, conventional system.