Abstract

VIROLOGIC RESPONSE IN THE TREATMENT OF INFECTION WITH ANTIVIRAL DRUGS

Oblokulov A.R.*, Oblokulov Z.I., Elmuradova A.A. and Farmanova M.A.

Abstract

There were studied epidemiological features of patients with HCVinfection who were under dispensary observation in clinics located in Bukhara Region, number of patients was 319, 110 (34.5%) of them were men and 209 (65.5%) were women. Etiological diagnostics of Chronic Hepatitis C was performed by the development of RNA and genotype of HCV infection in blood serum by the method of real-time polymerase chain reaction. It was detected that 63.9% (n. 204) of the patients had first, 0.5% (n = 18) of them had second, 21.9% (n=70) – third, 0.8% (n=27) – fourth genotype of the virus. Before antiviral therapy, in 22 (20%) in the main group of patients it was detected F0 fibrosis, so in 30 (27%) patients F1, in 36 (31.8%) patients F2 and in 23 (21%) patients F3. Fibrosis of F4 stage was revealed only in 2 (0.2%) patients. With the use of NS5B and NS5A RNA polymerase inhibitors, rapid virologic response was observed in 195 (95.6%) patients, early virological response – in 204 (100%), 200 (98%) of the patients achieved complete elimination of HCV RNA.

Keywords: HCV-infection, fibroscan, NS5B and NS5A RNA polymerase inhibitors.