Abstract

IN VITRO CYTOTOXICITY EFFECT OF MANGROVES AGAINST NON-SMALL CELL LUNG CARCINOMA A549 AND NCI-H522

C. Ravinder Singh and K.Kathiresan

Abstract

This is the study mainly focused on to find the anti-prolifertative effectof field grown and tissue cultured callus materials. The mangrovespecies Acanthus ilicifolius, Callophyllum inophyllum and Excoecariaagallocha and two different non-small cell lung cancer cell linesA549 and NCI-H522 were used for this present investigation.Cytotoxicity studies were conducted with root extracts of Acanthusilicifolius, Callophyllum inophyllum and Excoecaria agallocha and itsrespective calli. The results were recorded from different concentrationat different time interval. It is likely to point out that all the roots androot calli extracts these mangroves showed the toxicity activity. Theroot callus of all the studied mangrove extracts exhibited the betteractivity against both A549 and NCI-H522 than the field grown rootextracts. Among the different concentrations tried, 6.5 mg/ml was found to be the optimumconcentration for both the A549 and NCI-H522 lung carcinoma. This present study revealedthat the mangrove species Acanthus ilicifolius, Callophyllum inophyllum and Excoecariaagallocha have the anti-proliferative effect and it may lead to new drug development for thisleading cause of global disease.

Keywords: mangroves, A549 and NCI-H522 lung carcinoma, anti-prolifertative effect, root callus.