Abstract

TRANSFERSOMES: A NOVEL VESICULAR CARRIER FOR EFFECTIVE TRANSDERMAL DRUG DELIVERY (A REVIEW)

*Neha Chopra, Peeyush Kaushik, Hitesh Malhotra, Shaveta Sharma, Deepali Tomar, Ashish Mishra

Abstract

Due to the ability of lipid vesicles to bypass barrier characteristics of the skin, they have beenused as topical drugs in recent years. The new transdermal supply network is more favourable than conventional supply systems. Elastic vesicles are transfers that deliver great distortion. They are widely used in bioactive formulations in transdermal supplies. Several methods can be applied, including iontophoreses, electrophoresis, sonophoresis etc., to increase transdermal penetration. Some other types of those systems must include vesicular system and microneedles (liposomes, noisomes etc.) The thin constriction of the transfer ranges (5-10 times lesser diameter, than their own) distorts and passes with no noticeable loss. The transferable defect function increases the permeation of the medication. These can be a carrier for low or high weight medications like antifungals, anaesthetics, corticosteroids, etc. These can also act as anaesthetics. The inside of the cell lipid of the stratum cornea will easily penetrated the skin. They move on to a deeply hydrated stratum according to an osmotic gradient, following application of Transfersomes on skin. The presence of surfactants in the structure assistances to resolve the lipid in the cornea stratum and allows for high vesicular penetration. This study aims to form and evaluate penetration of the medicine and enhances its anti-fungal activity by using Serteconazole nitrate transfersomes. The results of the study are based on the percentage of surfactants. Dermatophytosis is used for the efficacy test as a model dummy disease.

Keywords: Ultra deformable vesicles; transfersomes; permeability; antifungal activity.