Abstract

ORAL GLUCOSE TOLERANCE, PHYTOCHEMICAL SCREENING, ACUTE TOXICITY AND ANALGESIC ACTIVITY EVALUATION OF LEAVES OF PHRYNIUM CAPITATUM

Joyanto Kumar Nandi, Samira Sultana, K.M. Hasanur Rahman, Shahnaz Rahman,Md Moshiur Rahman, Mohammed Rahmatullah*

Abstract

Oral glucose tolerance tests were conducted with methanolic extract of leaves of Phrynium capitatum in glucose-loaded Swiss albino mice. The extract, when administered at doses of 50, 100, 200 and 400 mg/kg, dose-dependently reduced blood glucose by 16.8, 26.3, 42.7, and 48.9%, respectively. Glibenclamide (a standard antihyperglycemic drug), when administered at a dose of 10 mg/kg reduced blood glucose level by 47.4%. In analgesic activity tests conducted with intraperitoneally administered acetic acid-induced pain model in mice, the extract at the afore-mentioned four doses reduced the number of abdominal constrictions, respectively, by 33.3, 37.0, 44.4, and 59.3%. A standard analgesic drug, aspirin, when administered at doses of 200 and 400 mg per kg reduced the number of abdominal constrictions by 48.1 and 63.0%, respectively. The results suggest that the leaves of the plant possess antihyperglycemic and analgesic potential and may be used for reducing blood sugar and for alleviating pain.

Keywords: Phrynium capitatum, marantaceae, antihyperglycemic, analgesic.