Abstract

IN VIVO EVALUATION OF ANTIDIABETIC AND ANTIDEPRESSANT POTENTIAL AND SIDE EFFECT STUDY OF AQUEOUS EXTRACT OF LEAVES OF CENTELLA ASIATICA ON ALLOXAN-INDUCED DIABETIC RAT MODEL

Amena Alam Shanta*, A.K.M. Mazedul Adnan, Md. Billal Hossain, Tahani Jashim, Rijve Ahamed, Tashdid Binte Kamrul, Fatema-Tuz-Zohra, Fahima Akhter Purni, Farhan Rashid and Sanzida Khondoker

Abstract

Diabetes is a metabolic disease and depression is a mental aliment plant derived merchandise are used to fight this both of disease, plant is a various supply of several therapeutic compounds which may be used to ameliorate diabetes & depression. Leaves of Centella asiatica is one of the leafy vegetables this is used for this cause traditionally. It has been used towards diabetes & depression for a very long time. Our aims have been to pick out the hypoglycemic & antidepressive effect of extract of leaves of Centella asiatica as well as to decide its protection profile so that we could use the plant material to enhance the diabetic & depressive situation. Diabetes changed into precipitated in rats with the aid of intraperitoneal injection of alloxan at a dose of 150 mg/Kg bodyweight and ethanolic extract of leaves of Centella asiatica changed into fed to the rats at a dose of 750 mg/kg. We measured blood glucose degree, and safety profile by means of measuring SGOT, SGPT and creatinine stage on diabetic and non-diabetic rats earlier than and after administration of the extract. After measuring blood glucose level, it turned into observed that the hypoglycemic efficacy was similar to that of metformin (p> 0.05) which become given at a dose of 500 mg/kg. Safety profile had been investigated by measuring the SGPT, SGOT and Creatinine Level. Become visible that both metformin and leaf extract of or plant can improve the pathological condition situation brought about by using diabetes, sucrose performance test and tail suspension test check has also shown extensive resopnse. Furthermore, in wholesome individual rats both metformim and leaf extract of Centella asiatica did no longer substantially alter the everyday physiological state. It might, therefore, be inferred that the extract of leaves of Centella asiatica might be used as a good alternative remedy to treat each diabetes & depression.

Keywords: Centella asiatica, Alloxan, Kidney functioning test, Liver functioning test, Alternative therapy.