Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL COMPOUNDS OF DIETHYL (((5 - ((1H - PYRAZOL - 1 - YL) METHYL) - 1, 3, 4 - THIADIAZOL - 2 - YL) AMINO) (4 - SUBSTITUTED PHENYL) METHYL) PHOSPHONATES

M. Swarna Kumari*, R. Ramadevi and K. Udaya Kumari

Abstract

New novel derivatives of Synthesis of 5 - ((1H-pyrazol - 1 - yl) methyl) - N - (4 - substitued benzylidene) -1, 3, 4 - thiadiazol - 2 - amines (3a - h). were prepared by condensation of we have reported the synthesis and characterization of Diethyl (((5 - ((1H - pyrazol - 1 - yl) methyl) - 1, 3, 4 - thiadiazol - 2 - yl) amino) (4 - substituted phenyl) methyl) phosphonates (4a - h). The newly synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectra & Elemental analysis. The newly synthesized compounds were screened for their Biological activity.

Keywords: 1,3,4-thiadiazole, Antibacterial and Antifungal activity, spectral data.