Abstract

THE ROLE OF DISINTEGRANTS IN SOLID ORAL DOSAGE MANUFACTURING

Anisur R. Khan*

Abstract

Disintegrants are agents added to tablet (and some encapsulated) formulations to promote the breakup of the tablet (and capsule “slugs‟) into smaller fragments in an aqueous environment thereby increasing the available surface area and promoting a more rapid release of the drug substance. In the other way Disintegrant are formulated to cause a rapid break-up of solids dosage forms when they come into contact with moisture.[6] Disintegrants are added to oral solid dosage forms to aid in their deaggregation. Disintegration is typically viewed as the first step in the dissolution process and promote the drug release by increasing the water wicking into the plug, and they promote deaggregation of the plug particles. For Immediate Release tablets disintegrant are essential, but for capsules, they are less important because the plug is less of a barrier to the drug release than a compressed tablet.

Keywords: Disintegrants, drug release, wicking, diaggregation.