Abstract

SYNTHESIS OF NOVEL THIOSEMICARBAZIDE DERIVATIVES OF DISUBSTITUTED N, N-DIMETHYLAMIOMALEIMIDES CHARACTERIZED BY ANALYTICAL TECHNIQUES

Sunita A. Chaudhari (Patil)*, Vasant M. Patil, Satish M. Chavan, Sambhaji V. Patil and Vishwanath R. Patil

Abstract

The compound 1 was reacted with bromine in DMF to obtained dibromosuccinimide 2. The compound 2 was reacted with N, Ndimethyl amine as a base followed by dehydrohalogenation to obtain 3-bromo-1-(4-chlorophenyl)-1H-pyrrole-2,5-dione 3 as a intermediate compound further on Vilsmeier Haack formylation afforded compound 4 with good yield. The condensation of 1- (4-halophenyl) -4 - (dimethylamino) -2, 5-dihydro-2, 5-dioxo-1H –pyrrole -3- carbaldehyde 4 with thiosemicarbazide hydrochloride in ethanol in presence of acetic acid furnished compound 5 with 81% yield. All the synthesized compounds were well characterized by spectral and analytical data. The synthesized compounds were evaluated for their insecticidal activity.

Keywords: Maleimide, N,N-dimethylamine, Vilsmeier Haack Formylation, Thiosemicarbazone.