Abstract

SYNTHESIS AND EVALUATION OF BIOLOGICAL ACTIVITY OF A NOVEL HETERO ARYL ACETIC ACID DERIVATIVE CONTAINING BENZIMIDAZOLE

Mariyam Jouhara B. M, Assoc. Prof. Arun Ramachandran, Asst. Prof. Ananya V. M, Fathimath Raihana, Anjana N. K, Ayishath Noureena, Asif K.

Abstract

A novel benzimidazole acetic acid derivative (1-H-benzoyl-1-Hbenzimidazol- 2- yl) acetic acid was synthesized by using O-phenylene diamine and formic acid as the precursor through three- step process. The functional groups were confirmed by IR spectroscopy. The newly synthesized compound was screened for antioxidant, antiinflammatory and antibacterial activities. The new derivative showed moderate antioxidant and anti-inflammatory activities in comparison with the ascorbic acid and indomethacin as standards respectively. According to Kirby-Bauer, the drug was sensitive to both gram positive and gram-negative bacteria. They showed activity similar to that of standard ciprofloxacin at a concentration of 5mcg/ml.

Keywords: Synthesis- Hetero aryl acetic acid derivative- Antioxidant activity - Antiinflammatory activity -Antibacterial activity.