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Abstract

DEVELOPMENT OF POLYMER CONJUGATED CEFACLOR FORMULATION WITH ENHANCED HALF LIFE AND BIOLOGICAL EFFECT

Rajshree Nema*, Arun Patel, Shailendra Patel and Neelesh Dwivedi

Abstract

Purpose of the study is to develop polymer conjugated cefaclor formulation with enhanced half life and biological effect. Antimicrobial drugs are the greatest contribution of therapeutics. Their advent changed the outlook of the physicians about the power drugs can have on diseases. Their importance is magnified in the developing countries, where infective diseases predominate. Cefaclor is a second generation cephalosporin antibiotic. Cefaclor is active against most strains both in vitro and in vivo clinical infections. Cefaclor is a grampositive and gram negative antibacterial drug, widely used for the treatment of certain human diseases. The drug acts as an inhibitor of cell wall synthesis of bacteria. The efficacy of cefaclor is hampered by its very short plasma half life. The objectives of present work were conjugation of cefaclor with mPEG and its characterization in order to increase the drug plasma half life. The PEG was taken for conjugation purpose because it is highly water soluble, practically non-toxic, non-immunogenic and approved by FDA. On the basis of above discussion it may be concluded that cefaclor conjugates with the PEG enhance its blood plasma half life. Our current investigation based on preliminary results focuses on the aspects that these conjugates of cefaclor with PEG could further be exploited as an efficient alternative to formulation of cefaclor.

Keywords: Cefaclor, PEG, Polymer Conjugated, half life and biological effect.


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