Abstract

ANTIOXIDANT AND ANTI-INFERTILITY EFFICACY OF NMIRACLE (POLYHERBAL FORMULATION) IN ETHANOL INDUCED INFERTILITY IN MALE ALBINO RATS

*Dr. Meenatchi Sundaram Angappan, Ph.D.

Abstract

The aim of this research was to investigate In-vivo enzymatic antioxidant and anti-infertility efficacy of N-Miracle (Polyherbal formulation) in ethanol induced infertility in male albino rats. A total of 30 male albino rats were selected, divided in to five groups. Ethanol induced testicular damage was done on Group III, IV, and V. The present study exhibited the enzymatic antioxidant impact of N-Miracle (Polyherbal formulation) against ethanol induced infertility in rats by increasing the levels of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and decreasing the activity of Glutathione-S-transferase in the liver. In the same time the polyherbal formulation increases the levels of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and decreasing the activity of Glutathione-S-transferase in the kidney. The present study showed androgenic effect of N-Miracle (Polyherbal formulation) by increasing testosterone and decreasing estrogen, LH, and FSH in ethanol induced infertile rats.

Keywords: Antioxidant, N-Miracle, Polyherbal formulation, Ethanol, Infertility, Testosterone.