Abstract

PREPARATION AND IN VITRO CHARACTERIZATION OF SUSTAINED RELEASE MATRIX TABLET OF METFORMIN HCL

Abhishek Dwivedi*, Dr. Arun Patel, Shailendra Patel and Neelesh Dwivedi

Abstract

The objective of this study was to prepare sustained release Metformin HCl matrix tablets using appropriate polymer in alone or combination and evaluate the in vitro release characteristics and to predict and correlate the release behavior of Metformin HCl from the matrix tablet and compare with marketed preparation. The low bioavailability and short half-life of Metformin Hcl (MH) make the development of sustained-release forms desirable. However, drug absorption is limited to the upper gastrointestinal (GI) tract, thus requiring suitable delivery systems providing complete release during stomach-to-jejunum transit. This study was undertaken to develop a MH sustained-release formulation in compliance with these requirements.

Keywords: DIABETES, METFORMIN, CARBOPOL, SUSTAINED-RELEASE, DRUG RELEASE KINETICS, SODIUM ALGINATE.