Abstract

SYNTHESIS, CHARACTERIZATION AND BIOCHEMICAL PROPERTIES OF NICKEL COMPLEXES OF AMINO ACIDS (HISTIDINE, METHIONINE)

Ruchi Dwivedi, I. P. Tripathi* and Vandana Pathak

Abstract

Ni(II)-amino acids coordination compound having octahedral stereochemistry, the general formula [NiL2Cl2] where L= Methionine, Histidine ratio(1:2) have been synthesized and characterized by element analysis, molar conductance and FTIR bonding pattern between metal ion and ligand show similar to each others. Electrochemical behaviour of the entire synthesized compound was studied using cyclic voltametry. Free radical scavenging activity (DPPH assay, ABTS assay) and anti-diabetic activity (α-glucosidase inhibition assay) was performed and found that both the activities showed moderate inhibition. The study will be helpful to provide an alternative remedy for the cure and treatment of targeted disease.

Keywords: Synthesis, Amino acids, DPPH, Complexes.