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Abstract

ANTIOXIDANT AND LIPID PROFILE EFFECTS OF TANNIC ACID IN STREPTOZOTOCIN INDUCED DIABETIC MALE WISTAR ALBINO RATS

Mba, O.J.*, Edward, U.I. and Umeh, V.A.

Abstract

This study was aimed to evaluate the antioxidant and lipid profile effects of tannic acid in streptozotocin induced diabetic male wistar albino rats. Fifty four (54) male albino rats of mean weight 140 g were used for this study. The animals for the study were grouped into nine (9) groups of six (6) rats each. Groups (1), (2) and (5) were the control groups. Groups (3), (4) and (6) were the test groups, while groups (7), (8) and (9) were the groups that received the extract only. Group 1 is the normal control that received feed and water only, group 2 is the negative control group that was induced with diabetes without treatment, and group 5 is the positive control that was treated with 50 mg/kg body weight of the standard drug (glibenclamide). Test groups (3), (4) and (6) were orally given 100, 200 and 400 mg/kg body weight of tannic acid. Groups (7), (8) and (9) were the groups that received the extract only (100, 200, and 400 mg/kg body weight of tannic acid). All the rats used in this study were initially subjected to diabetes by single intraperitoneal induction of 65 mg/kg body weight of streptozotocin except the normal control group and the groups that received the extract only. Treatment lasted for 21 days and after which the animals were sacrificed under mild anesthesia (10% formasaline). Blood samples were collected in the plain bottle for the analyses on the antioxidant and lipid profile effects of tannic acid in diabetic rats by assessing biochemical parameters such as total cholesterol, high density lipoprotein, low density lipoprotein, triacylglycerol, very low density lipoprotein, superoxide dismutase, catalase, malondialdehyde and reduced glutathione. From the result obtained, there was a significant (p< 0.05) increase between the negative control and the test groups that received 100, 200 and 400 mg/kg body weight of tannic acid and the groups that received the extract only (100, 200 and 400 mg/kg b.wt of tannic acid) for catalase (CAT) and malondialdehyde (MDA), while there was a significant (p< 0.05) increase between the negative and the test groups that received that 200 and 400 mg/kg b.wt of tannic acid and the groups that received the extract only (100, 200 and 400 mg/kg b.wt of tannic acid) for reduced glutathione (GSH). For superoxide dismutase (SOD), there was a significant (p< 0.05) decrease between the negative and the test groups that received 100, 200 and 400 mg/kg b.wt of tannic acid and the groups that received the extract only (100, 200 and 400 mg/kg b.wt of tannic acid) Also there was a significant (p< 0.05) decrease in triacylglycerol (TAG), total cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) between the negative control and the test groups that received 100, 200 and 400 mg/kg b.wt of tannic acid and the groups that received the extract only (100, 200 and 400 mg/kg b.wt of tannic acid), while there was a significant (p< 0.05) increase between the negative and the test groups that received that 200 and 400 mg/kg b.wt of tannic acid and the groups that received the extract only (100 mg/kg b.wt of tannic acid) for high density lipoprotein (HDL).The study indicates that tannic acid may have exerted antioxidant and hypolipidemic effects in streptozotocin induced diabetic male wistar albino rats, and may also be used pharmacologically in the management of hyperlipidemia and diseases implicated by free radicals.

Keywords: Antioxidants; Catalase; Reduced glutathione; High density lipoprotein; Low density lipoprotein; Superoxide dismutase; Total cholesterol.


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