Abstract

RESISTANCE OF OSELTAMIVIR: A MAJOR PROBLEM FOR SWINE FLU TREATMENT

Mukesh Kumar Gupta*, Anil Agrawal, Kiran S. and Krishnagopal Parihar

Abstract

Swine flu is a fast emerging life-threatening disease caused by the H1N1 influenza virus. It is spreading every year through changing its strains. The H1N1 (swine flu) is a new strain of flu virus that caused a pandemic worldwide in 2009 and result global health problems. Oseltamivir, Zanamivir, Adamantine, and Rimantadine were the drugs, which are effective against the H1N1 strain. Oseltamivir was a drug of choice for swine flu but it showed several adverse effects, cost problems, and became resistant against H1N1 virus. Oseltamivir was not very effective in 2008 against seasonal H1N1 virus due to acquired resistance (99.6% of H1N1), and up to 12% against the flu virus. Due to resistance, and the emergence of new strains, nowadays oseltamivir is not in prescription using nowadays. Presently there is no drug of choice for swine flu and still, it is a challenge to develop new drugs against changing strains of the H1N1 flu virus. This review highlights and rational guide to the problems associated with NA inhibitor oseltamivir, and design and development of novel drug (s) for the treatment of swine flu.

Keywords: H1N1, Mutation, Neuraminidase, Oseltamivir, Resistance, Shikmic acid and Swine flu.