Abstract

STUDIES TOWARD THE DESIGN NATURAL POLYMER BASED HYDROGEL AS CHITOSAN FOR USE IN PREVENTION OF BIOFILM

Nandedkar Mugdha*, Oswal Rajesh, Pardeshi Kalyani, Raut Samruddhi, Magar Snehal, Mahajan Sneha, Shinde Komal and Rele Harshal

Abstract

Active pharmaceutical ingredients and pharmaceutical excipients are the core of any pharmaceutical preparation. API‘s are responsible for the therapeutic activity while excipients are non-pharmacological ingredients which are used in the manufacturing of pharmaceutical preparations. Chitosan is a polysaccharide that contains many polar functionalities like amino and OH (hydroxyl) groups, which make the polymer hydrophilic and amenable to forming 3-D structures. Chitosan-based hydrogels are capable of absorbing large quantities of water while retaining structural features. Using a variety of strategies based on ionic, polyelectrolyte, chemical modification, and interpenetrating network techniques, chitosan-based hydrogels have been designed and investigated to deliver therapeutics to the site of action in a controlled manner. In this review we present an overview of hydrogels that have recently been developed and when possible provide a discussion relevant to their mechanism of action.

Keywords: Polymer, Chitosan, Hydrogel, Biofilm.