Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF NOVEL PEDIATRIC SUSPENSION FOR ANTIDIABETIC DRUG GLIBENCLAMIDE

Vanitha K., Divya S. Kumar, Gururaj S. Kulkarni* and Dr. Padmaa M. Paarakh

Abstract

Background: Glibenclamide is a second-generation oral sulfonylurea and most widely used in the treatment of NIDDM and more effective and safer than first-generation agents. In recent days diabetes is diagnosed in children and tablets may not ideal for child patients by oral route. Here an attempt is made to prepare and evaluate the oral suspensions of Glibenclamide for diabetic children. Objectives: The main aim of this project is to prepare novel pediatric suspension of anti-diabetic drug using NaCMC and Xanthan gum as a suspending agent with different concentration of polymers and size reduction of drug. Methods: The particle size of the drug was reduced and moistened with wetting agent and triturated with suspending agent in glass mortar pestle to form smooth paste. Preservative, buffering agent, etc., are added and mixed well by stirring. Added sufficient quantity of deionized water to make the final volume. Results: The prepared suspensions were evaluated for drug uniformity, particle size, pH, sedimentation volume, viscosity, redispersibility, flow rate, in vitro dissolution studies. F11 formulation having Xanthan gum 0.5%, drug particle size 80μm was found to show the better results as compared to other formulations. Conclusions: The sedimentation volume was increased with decreasing the particle size of drug. F11 formulation was selected as the best formulation. It showed 0.60 F Sedimentation volume, 662Cps Viscosity, 98.5±0.4 % CDR, and 98.85±0.490 % drug content. The stability study of formulation F11 found that there is no change in the characters of suspension after 3months.

Keywords: Glibenclamide, Particle size, NaCMC, Xanthan gum, Suspension, etc.