Abstract

CASE REPORT ON AN EFFECTIVE AGENT IN MANAGING HYPERCALCEMIA WITH SEVERE RENAL IMPAIRMENT

Mahesh D. M.*, Vinay Patil, Praveen Kumar and Anand Srivastava

Abstract

Bisphosphonates are first line drugs in the acute management of hypercalcemia in those with normal kidney function, but are contraindicated in those with patients with low GFR. In those with renal dysfunction, both over hydration and bisphosphonates cannot be used, thus making it difficult to reduce calcium levels and hence patients are subjected to haemodialysis and its risks. We report a case of bilateral renal calculi and acute kidney injury secondary to primary hyperparathyroidism (PHPT) with severe hypercalcemia (12.3 mg/dL), in whom denosumab (RANKL inhibitor) was used to effectively lower the calcium levels.

Keywords: Hypercalcemia, Renal dysfunction, Hyperparathyroidism, Denosumab.