Abstract

MICROWAVE SYNTHESIS- CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF NOVEL LIGAND (2, 6- DIACETYLPYRIDINE AND 5-AMINO-1, 3, 4- THIADIAZOLE-2-THIOL) AND ITS METAL COMPLEX

Dr.Mohammed.Fakruddin Ali Ahamed*, Segni Asafa

Abstract

Metal complexes of Cu (II) with a new Schiff base derived from 2,6- Diacetyl pyridine-5-amino -1,3,4-thiadiazole -2-thiol (DAPATT) in methanol are reported. The complexes have been characterized using chemical analysis, (IR, UV-VIS, H1-NMR), conductometric data. According to these data, we propose an octahedral geometry for metal (II) complexes. The invitro antibacterial activities of the investigated complexes were evaluated against few microorganisms by well diffusion technique. It was found that the metal complexes have higher activity that the standard drugs. Antibacterial activity of the ligand and its complexes were studied against to gram positive bacteria; Staphylococcus aureus and bacteria Salmonella typhi and Escherichia coli

Keywords: Hexa-dentate Schiff base, 2,6-Diacetyl pyridine-5-amino -1,3,4-thiadiazole - 2-thiol (DAPATT), Biological activity.