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Abstract

RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF CEFIXIME TRIHYDRATE AND CLOXACILLIN SODIUM FROM BULK AND TABLET DOSAGE FORM

M. Sandhya Madhuri*, K. Rama Priyanka

Abstract

A simple and effective RP-HPLC method has been developed for the estimation of cefixime and cloxacillin in combination on C8 HiQsil column using phosphate buffer pΗ(3): acetonitrile, (70:30v/v) as mobile phase at flow rate of 1ml/min. Detection carried at 225 nm. Retention time found to be 2.120 for cefixime and 6.107 for cloxacillin. The linear dynamic ranges were 2-12μg/ml (r²>0.999) for cefixime trihydrate and 5-30μg/ml (r²>0.995) for cloxacillin sodium, respectively. The mean percent recovery was found to be 100.314% for cefixime trihydrate and 100.830% for cloxacillin sodium. The method was quantitatively evaluated in terms of linearity, precision, accuracy (recovery), selectivity and robustness in accordance with ICH guidelines. The obtained results show the proposed RP-HPLC method is simple, rapid, precise, accurate and cost effective which is useful for the routine determination of cefixime trihydrate and cloxacillin sodium in bulk drug and in its tablet dosage form.

Keywords: Cefixime trihydrate and Cloxacillin, RP-HPLC, Method Validation.


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