Abstract

FORMULATION, DEVOLOPMENT AND EVALUATION OF MICROSPHERES OF ANTI-VIRAL DRUG USING VARIOUS HYDROPHILIC NATURAL GUMS

Siddhartha Choudhury*

Abstract

The main objective of this research work was to formulate and evaluate the microspheres of various hydrophilic natural sources occurring guar gum and xanthan gum in the view of bio-degradable, easy of availability, cheap, widely use and drug release rate controlling agent with antiviral drug. Lamivudine is an antiviral drug having biological half life of 4-6 hours and bioavailability is 86% for the treatment of HIV as well as Hepatitis-B. Similarity study was carried out by using FT-IR at the range of 400 to 4000 and show no significant change in the characteristic peak. Microspheres of Lamuvidine were prepared and analyzed by solvent evaporation technique using liquid paraffin. The prepwas are microspheres were subjected to various evaluation parameters such as flow and micromeritics properties, particle size analysis and stability study. In- Vitro drug release using USP dissolution rate apparatus type-II (paddle method)and data was subjected to various kinetic models. Microspheres thus obtained were found to free flowing, spherical shape and pale yellow in color. The Scanning Electron Microscopy (SEM) studies inferred the spherical shape and size range of 100micrometre to 200micrometer for the total of 9 formulations(F1.F2,F3,F4,F5,F6,F7,F8 &F9) and drug release shows decreases as concentration of xanthan gum, increases and release rate was zero order and Fickian diffusion controlled. Stability studies were carried out which indicate that selected formulations was stable. The research concluded that microspheres offer to prepare controlled release of Lamuvidine with xanthan gum as rate controlling agent to reduce in dose frequency and increase bioavailability.

Keywords: Lamivudine, various natural gums, solvent evaporation, oral controlled drug delivery.