Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF METFORMIN HYDROCHLORIDE USING SODIUM ALGINATE AND PECTIN: A REVIEW

Vikash Jakhmola*, Vikas Bhatt and Aneek Chakraborty

Abstract

This study was aimed to formulate and evaluate matrix tablets of Metformin HCl using Sodium Alginate/Pectin polymer. Matrix tablets were prepared by direct compression method in different drug polymer ratios. Drug & polymers interaction was assessed by FTIR spectroscopy & results indicated absence of chemical interactions between them. The physico- chemical compatibility of the drug with polymer was evident from the thermal analysis using DSC. The thermogram obtained showed distinctive and characteristic exothermic peaks of the API indicating its crystalline nature. Blends prepared using different drug polymer ratio were evaluated for pre-compression studies and formulated matrix tablets were evaluated for weight variation, thickness, hardness, friability and Drug content. In-vitro release studies of the matrix tablets were carried out in acidic buffer (pH1.2) as well as in phosphate buffer (pH 6.8) along with the evaluation of Swelling & Erosion studies behavior if the tablets. It is evident from in-vitro drug release studies that, the drug release decreases with increase in the amount of polymer added. Studies also indicated that the extent of swelling and erosion of matrix tablets influences the drug release. A bi-phasic release with an initial burst effect in the matrix tablets is evident from the data obtained. Swelling and erosion studies of Metformin tablets indicated that matrix tablets swell almost from the beginning and its erosion increase with swelling and the time. Cumulative drug release in percentage was found to be sustained for all formulations. The best formulation was MA3 with 93.06% drug release in 12th hr. From further extrapolation of the drug release data it is evident that out of the total 9 formulation studied, seven formulations were good fitted into Korsmeyer-Peppas model and rest of the two formulations were good fitted in Higuchi matrix model.

Keywords: Matrix Tablet, Drug release, Swelling, Erosion, Pectin, Sodium Alginate, Metformin HCl.