Abstract

NIOSOME: A PROMISING NOVEL DRUG DELIVERY SYSTEM FOR THE NATURAL DRUG THROUGH BLOOD BRAIN BARRIER

A. R. Ghumare*, S. G. Talele, A. A. Chaudhary, A. P. Kothawade, R. S. Pawar, A. G. Jadhav

Abstract

Niosomes are considered as novel drug delivery systems (NDDS), are non-ionic surfactant vesicles produced by hydrating blend of cholesterol and nonionic surfactants. It can be utilized as carriers of amphiphilic and lipophilic drug. In niosomes drug delivery system, the medication is encapsulated in a vesicle. Niosomes are exhibit flexibility in their structural characterizations, main property is biodegradable, biocompatible non-immunogenic. Can enhance the solubility, stability of pharmaceutical molecules. They are invented to provide targeting and controlled release of natural pharmaceutical compounds. the preparation method, type and amount of surfactant, drug entrapment, temperature of lipids hydration, and nature of drug molecules are some major factor which can influenced drug targeting, therapeutic application of noisome. The main objective of this article is the application of niosome technology is used to treat a number of diseases, niosome are have excellent good opportunity in research and beneficial for pharma industries. It also provides recent data about the various types of ligand agents which are able to give active targeting drug delivery to the central neuron system.

Keywords: Niosomes, Compositions, Methods of Preparation, applications, characterization.