Abstract

CYTOPROTECTIVE POTENTIAL OF WITHANIA SOMNIFERA AGAINST ENDOSULFAN ON OVARY OF FEMALE MICE

Poonam Kumari*

Abstract

In the recent times, indiscriminate use of pesticides has increased many folds. The farmers for the better yield of crops are utilizing the pesticides. Presently, these pesticides have caused health related problems in the population. It has led to hormonal imbalance in females leading to infertility. The present research work on animal deciphers the antidote effect of withania somnifera in endosulfan induced ovarian toxicity in female mice. Endosulfan at the dose of 3mg/Kg body weight was administered orally to female mice for respectively 1 week, 2 weeks, 3 weeks & 4 weeks. Thereafter withania somnifera at the dose of 1000mg/Kg body weight was administered for 4 weeks to observe the positive effect of it on ovarian cells. The study reveals that after the administration of endosulfan, there was significant damage at the sub cellular level in ovarian cells of mice but after administration of withania somnifera there was significant reversal at the sub cellular levels. The basic property of withania somnifera eliminates the deleterious toxicity of endosulfan denotes that it not only possesses antioxidant and rejuvenating property but also maintains the cellular integrity of the ovarian cells leading to normal functioning of it.

Keywords: Endosulfan; Withania somnifera; Oocytes; Mice; Electron Microscopy.