Abstract

ANTIHYPERTENSIVE ACTIVITY OF Nardostachys jatamansi IN HYPERTNSIVE RATS FOLLOWING RENAL GOLD BLATT OCCLUSION METHOD.

V.Velpandian*, N.Anbu, S.Elangovan, M. Mohamed Musthafa

Abstract

Siddha drugs are gaining popularity in recent years and there is asignificant increase in scientific researches on traditional Siddha drugsbecause of theirs potent effects with no or less adverse effects.One ofthe safest and potent anti-hypertensive drug from the reservoir inSiddha system of medicine is Sadamanjil Chooranam (Nardostachysjatamansi). Hence an attempt was made to validate the antihypertensivepotential of Sadamanjil Chooranam in hypertensive ratsfollowing renal Goldblatt occlusion method. After induction,hypertensive rats were randomly divided into four groups each consistsof five rats. All the groups were categorized into normal control,hypertension control, SMC 500 (500mg/kg) and SMC 1000(1000mg/kg). The test drug Sadamanjil Chooranam was administered(500mg/1000mg/kg) orally from the next day for 10 days. The systolic (SBP) and diastolic(DBP) blood pressure of the animals were recorded with tail cuff BP apparatus.Administration of SMC at the dose levels of 500mg and 1000mg /kg b.w. for 10 dayssignificantly decreases the Systolic BP and Diastolic BP as compared with hypertensiveanimal group. Decrease in systolic and diastolic BP was more pronounced in high dose level(1000mg/kg) than low dose (500mg/kg) indicated the dose dependent activity of SadamanjilChooranam. The results concluded the anti-hypertensive potential of Sadamanjil Chooranamin a scientific way.

Keywords: Nardostachys jatamansi, Sadamanjil Chooranam, Siddha, anti-hypertensive, Gold Blatt method.