Abstract

A NOVEL APPROACH FOR VACCINE DEVELOPMENT IN VIVO AT PRESENT AND FOR FUTURE – A REVIEW ARTICLE

*Dr. Ajit V. Pandya and Kavya Pandya

Abstract

The viruses evolved in nature or cultivated in laboratory are very high in frequency as compared to vaccine development and therapeutic medicines. The skin is a dynamic organ that contains different cells which contains elements of the innate and the adaptive immune systems which are activated when the tissue is under attack by invading pathogens. Immobilization mechanisms of viral proteins and other biomolecules attach to surfaces by several different mechanisms are to be used on trial and error-based methods to standardized the protocol for vaccine production. This will be 100% efficient and sure personalized in vivo vaccine so no side effects. The immunological relationship between various viral antigens is one of the important subjects for serodiagnosis of antigens of viruses. The binding ability of the attenuated or live virus-modified surfaces were investigated using the laser-spotted microarrays. Author has discussed various theories supporting practical approaches which were used for other purpose but not for vaccine production - which is an immediate need for development of safe vaccines in present and future. Preclinical studies should be designed to assess the relevant immune responses, e.g., seroconversion rates, geometric mean antibody titers, or cell-mediated immunity in vaccinated animals and in humans successively. Immunogenicity studies may include the characterization of antibody class, avidity, affinity, half-life, memory and potential induction of cell mediated immunity as well as release of soluble mediators affecting the immune system as appropriate.

Keywords: Virus, vaccine, immobilization, immunization, clinical trials.