Abstract

FORMULATION AND EVALUATION OF FLOATING TABLETS OF ACYCLOVIR USING NATURAL POLYMERS

Avinash S. Gudigennavar*, Anita R. Desai, Jaydev Hiremath, Prabhu Halakatti, Sachin M. Vathare

Abstract

The aim of the present work is to formulate and evaluate floating tablet of acyclovir using natural polymers by direct compression method. The floating tablets of Acyclovir were prepared by direct compression method, Hibiscus rosa sinensis (HRS) leaves mucilage and xanthum gum used as a natural rate controlling agents. Sodium alginate used as a semi-synthetic rate controlling agent. Different excipient are used to formulate tablets. The physicochemical parameters like precompression and post-compression evaluation were performed as per pharmacopoeia standards and compatibility study was done by FTIR method. The release data were subjected to different models in order to evaluate their kinetics and release mechanism. The FTIR spectral analysis showed that there was no drug interaction with formulations additives. Pre-compression parameters showed good flow properties. Post compression parameters shown good results. Formulation F3 and F9 showed good results throughout the study. Short term stability studies on the formulations F3 and F9 indicated that there are no significant change in the hardness, friability, disintegration time, drug content and in-vitro drug release study. Result revealed that the floating tablet of acyclovir containing rate controlling agents such as xanthum gum with conc. 21% (F3) and mucilage of Hibiscus rosas sinesis leaves with conc. 21% (F9) are showed shorter floating lag time and better cumulative drug release profile as compared to sodium alginate.

Keywords: Gastro retentive floating tablet (GRFT); Acyclovir; Hibiscus rosa sinensis (HRS); Natural polymers; Floating drug delivery system (FDDS).