Abstract

ACCELERATED STABILITY STUDIES OF KANTAKARI AVALEHA AND ITS GRANULES

U.R.S.R.K. Senarathna*, Swapnil Choudhri and Bishwajyoti Patgiri

Abstract

Introduction: Kantakari Avaleha (KA) is merely herbal medicine used to treat Shwasa, Kasa, Hikka and Arati since Vrinda Madhava period. It is observed that KA degrade early than the other Avaleha forms; however, the stability study of KA was not carried out till date. KA was modified to its granular form by aiming increase shelf life as well as increase palatability. Aim: To evaluate the accelerated stability of KA and its granules. Materials and Methods: Finished formulations of each KA and KAG were packed in three airtight food graded plastic containers separately. one pack from each sample were analyzed just after manufacturing and remaining two packs were kept in stability chamber at 40°C ± 2°C/75% ± 5% RH, of which one pack was analyzed after the completion of three and another after 6 months. Organoleptic, physico‑chemical, microbiological parameters along with high‑performance thin layer chromatography (HPTLC) fingerprinting were carried out. Results: Organoleptic characters were not significantly changed at the end of the 6 month in accelerated stability Condition. HPTLC fingerprinting showed minimum changes and microbial studies were in confirmation to the World Health Organization guidelines. Conclusion: KA and KAG confirmed to the International Conference on Harmonization Guideline for accelerated testing of the pharmaceutical product on said parameters and as per the Grimm’s statement the shelf life of KA and KAG may last 13.05 and 14.48 months.

Keywords: Accelerated stability study, shelf life, Kantakari Avaleha, Kantakari Avaleha granules.