Abstract

IVABRADINE HYDROCHLORIDE LOADED TRANSDERMAL DRUG DELIVERY SYSTEM ITS FORMULATION AND EVALUATION

Prothibha Das*, Minnu George, Praveen P. L., Aswathy Sivaraman and Soji S.

Abstract

An attempt was made to develop the complete transdermal system of the drug by using backing membrane and release liner. From this study it can be concluded that it is possible to design a transdermal drug delivery system for Ivabradine HCl, where therapeutic efficacy and patient compliance are of prime importance. However, long term pharmacokinetic and pharmacodynamic studies are needed to be undertaken to establish the usefulness of these patches. Ivabradibe Hydrochloride is a selective inhibitor of cardiac If channel, mainly used in the treatment of stable angina pectoris. It is rapidly and almost completely absorbed after oral administration, but it undergoes greater than 50% first pass metabolism. The polymers used in this study were a blend of eudragit RS 100 and HPMC in first combination of formulations (A1-A5) and eudragit RL 100 and HPMC in the second combination (B1-B5). The plasticizer used was tri-ethyl citrate. The patches were prepared by casting method and the formulated patches were evaluated for various physicochemical parameters. Second combination of films the B2 formulation with eudragit RL 100 to HPMC ratio 2:3 released 89.35% in 24hrs, showed the thickness of 0.146±0.011 mm and drug loading of 97.37% was showed the best results.

Keywords: Ivabradine hydrochloride, Angina pectoris, Transdermal Patches, Polymers.