Abstract

ACUTE AND SUB ACUTE TOXICITY STUDY OF THE SIDDHA DRUG UTHAMANI CHOORANAM (PERGULARIA DAEMIA)

S. Jayasree *, M. Subashini, D.P. Sangeetha, V. Banumathi

Abstract

Atopic Dermatitis (AD) is a chronic, highly pruritic inflammatory skin disease, and is one of the most common skin disorder in children. Uthamani Chooranam has been employed as a traditional remedy for Atopic dermatitis (AD), which is a herbal formulation containing whole plant of Pergularia daemia. As a mandate, steps were taken to evaluate safety profile of UC in rats using OECD guidelines. Swiss albino rats of either sex weighing 220-240 gm were used. Acute and Sub-acute toxicity studies were carried out as per OECD guidelines 423 and 407. Haematological, biochemical parameters, histo pathological study were performed for all animals. The study concludes that on oral administration of 200 and 400 mg/kg body weight of UC to swiss albino rats, no change in behavioural and characteristic clinical sign of toxicity was observed.The UC was found to be safe in animals. No toxic effect was observed in both acute and sub-acute toxic studies of Uthamani Chooranam.

Keywords: Uthamani Chooranam, OECD, Atopic Dermatitis.