Abstract

MASKING OF BITTER DRUG BY USING ION EXCHANGE RESIN METHOD

Dighe Ajinkya D.*, Bidkar Shital J., Naykodi Pradnya S., More Komal V., G. Y. Dama

Abstract

The lamivudine is bitter in taste API. Undesirable taste is one of the several important formulation problem that are encounter with certain drug the present study deals with development of taste masked resonates of Lamivudine using ion exchange resin. The drug resin complexation procedure was optimize with respect to drug to resin ratio, stirring time and pH of medium. The taste masked complex was characterized by FTIR, DSC. In-vitro release studies elevated complete drug release within 120 min in 0.1N HCL solution. The taste masked complex was than formulated into a oral film dosage form using Glycerin, pectin and citric acid. The oral film was evaluated for various quality control parameter

Keywords: Bitter taste, Taste masking, oral film, lamivudine, resinate, Ion exchange resin.