Abstract

AN EMANATION OF NAIL LACQUER IN THE MANAGEMENT OF NAIL DISORDERS: A COMPREHENSIVE REVIEW

Dr. Surender Verma*, Shweta Rani* and Akash Yadav

Abstract

Transungual drug delivery is contemplated to be extremely feasible to cure nail disorder as well receiving increasing attention. The topical treatment due to its local effect bypasses the systemic adverse events cognate with systemic treatment, ameliorates patient compliance lowers treatment cost. The majority of fungal infection is prompted by dermatophytes, yeasts, and molds which digest keratin for replication and growth. Undoubtfully, treating fungal infection avail oneself of topical delivery is difficult and slightly given the presence of complex barrier of nail structure and an insufficient number of methods available to achieve MIC of the drug within the nail bed or nail matrix. Treatment efficacy is estimated by the route of entry of antifungal drugs within the nail plate and adjacent nail bed. The subungual route is observed as a significant or key method of drug delivery into a nail. The current review outlines nail structure and physiology, various onychopathies, several novels approach for nail permeation enhancement, factors affecting permeation and uptake of the drug into the nail bed, models used for in-vitro studies, updated data on developed formulation and outcomes with antifungal therapy. Successful topical products for the management of nail infections need to be further research.

Keywords: Nail matrix, Onychopathies, Permeation enhancements, Subungual, Transungual drug delivery system (TUDDS).