Abstract

FORMULATION AND EVALUATION OF MUCOADHESIVE MICROSPHERES OF LORATADINE FOR NASAL DRUG DELIVERY

Rajaram* and Shalini Singh

Abstract

Intranasal administrative is an ideal alternative to the parenteral route for systemic drug delivery. Nasal mucosa consists of a rich vasculature and a highly permeable structure for systemic absorption. Drug administration through the nasal cavity is easy and convenient. Avoidance of first pass metabolism is the main advantage of nasal route drug delivery. Bioadhesive polymers are used as drug carriers for the nasal drug delivery. The advantage of using Bioadhesive polymer is increase in residence time of the formulation in the nasal cavity and thereby minimizing rapid mucociliary clearance of the therapeutic agent from the site of deposition.

Keywords: Loratadine, Mucoadhesive, Transdermal, Bioadhesive, Polymers, Nasal Delivery, Microspheres.