Abstract

MONOCLONAL ANTIBODIES USED IN THE TREATMENT OF HAEMATOLOGICAL MALIGNANCE AND SOLID TUMOUR

Ganachari R. V., *Shaikh P. H., Buye S. S., Sarnaik S. S. and Shaikh A. A.

Abstract

Monoclonal antibody (mAbs) are a widespread and necessary tool for biomedical science, In the haematological cancer field, since rituximab became the first mAb approved by the Food and Drug Administration for the treatment of B-cell malignancies, a number of effective mAbs targeting lineage-specific antigens (LSAs) have been successfully developed. Alongside surgery, Radiation and Chemotherapy, Monoclonal antibody shows or possesses diverse set of clinically relevant mechanism of action and in addition, antibodies can directly target tumour cells, while simultaneously promoting the induction of long-lasting antitumor immune response.

Keywords: Monoclonal antibody, Cancer tumour, haematological cancer, Cancer treatment, Immunotherapy, Autoimmune disease.